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Enzyme and Microbial Biochemistry Lab
Department of Chemistry, IIT Delhi
Antimicrobial Resistance
(AMR)
Our research focuses on the exploration of rare actinomycetes as potential sources of novel antimicrobial agents.
Actinomycetes, a diverse group of bacteria found in soil and aquatic environments, have long been recognized for their ability to produce bioactive compounds with antimicrobial properties.
Our work involves the isolation and characterization of these rare actinomycetes, with a keen focus on their antimicrobial activities against a range of clinically relevant pathogens. Through rigorous screening and advanced molecular techniques, we aim to identify novel compounds capable of overcoming antimicrobial resistance mechanisms.
Selected Publications
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Nikky Goel, Saniya Zaidi, and S.K. Khare. Whole genome sequencing and functional analysis of a novel biofilm-eradicating strain Nocardiopsis lucentensis EMB25. World Journal of Microbiology and Biotechnology, 39, 292, 2023
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Nikky Goel, Moumita Ghosh, Deepti Jain, Rajeshwari Sinha, and S.K. Khare . Inhibition and eradication of Pseudomonas aeruginosa biofilms by secondary metabolites of Nocardiopsis lucentensis EMB25. RSC Medicinal Chemistry, 14(4), 745-756, 2023
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Huma Fatima, Amrik Bhattacharya and S.K. Khare . Efficient remediation of meropenem using Bacillus tropicus EMB20 ß-lactamase immobilized on magnetic nanoparticles. Journal of Environmental Management,329, 117054, 2023
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Huma Fatima, Sumit Kumar and S.K. Khare . Insights from the genome sequence of Bacillus tropius EMB20, an efficient ß-lactamase producing bacterium. 3 Biotech, 12, 1-9, 2022
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Nikky Goel, Rajendra Singh, Seema Sood, S.K. Khare . Investigation of Streptomyces sp. Strain EMB24 Secondary Metabolite Profile Has Unraveled Its Extraordinary Antibacterial Potency Against Drug-Resistant Bacteria. Marine Biotechnology, 24, 1-8 , 2022
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